Abram Hoffer, MD, PhD (1917-2009), Orthomolecular Medicine, (with Double Nobel Prize Winner Dr. Linus Pauling) was a world-renowned Canadian doctor and biochemist that treated over five thousands of patients with mental disorders (including schizophrenia, drug/alcohol addiction, psychosis) through better nutrition , micronutrients, and megavitamin therapy. Dr. Abram Hoffer, a pioneer of holistic nutritional/vitamin therapy, died in May 2009 at the age of 91. For over 50 years, Dr. Abram Hoffer personally took 4,500 mg (4.5 grams) of Niacin (Vitamin B-3) along with other supplements. Dr Abram Hoffer was a prolific researcher and writer, wrote over 30 books and 600 peer-reviewed medical journal articles (most of which were ignored by mainstream medicine) and was productive until 2 weeks prior to his death (age 91). Mary MacIsaac (1893-2006): Oldest Person in Canada , friend of Dr. Abram Hoffer Oldest human in Canada, Canadian Supercentenarian, Mary MacIsaac (27 December 1893 - 10 March 2006) was a friend of Dr. Abram Hoffer . Ms. Mary MacIsaac, Canadian's oldest person, age 112, died on March 10, 2006. Mary MacIsaac was Canada's oldest person and 19th-oldest in the world. But Mary MacIsaac differed significantly from the others, for Ms. MacIsaac had been taking niacin for forty years before she died. Ms. Mary MacIsaac had cross-country skied until 110 and was photographed playing a piano duet with her great-grandson just before she died. Ms. MacIsaac was weaker, but her mind was clear when she died after a brief illness. Mary MacIsaac credited the Niacin and perhaps she was correct, because Niacin (vitamin B-3) does have remarkable anti-aging and life-extending properties, according to Dr. Abram Hoffer. Dr. Abram Hoffer with AA Founder of AA (Alcoholics Anonymous), "Bill W" (Bill Wilson) was a friend of Dr. Abram Hoffer, and followed Abram Hoffer's program for many years . "Bill W" (Bill Wilson) took 3000 mg of Vitamin B3 (Niacin) and 3000 mg of Vitamin C daily.